Results of an international multicenter study of release-active antibodies to interferon gamma in the treatment of influenza and acute respiratory viral infections in children
Influenza and other acute respiratory viral infections (SARS) are the most common diseases in the child population. Annual ARVI outbreaks are caused by respiratory viruses of 5 groups, including more than 300 subtypes, which determines a variety of clinical symptoms, on the one hand, and the complexity of etiotropic therapy and vaccine prevention, on the other. The most severe forms of respiratory infections are caused by influenza viruses. Of particular danger are pandemic strains of the influenza virus. Other acute respiratory viral infections caused by various respiratory viruses are also highly contagious, the formation of mixed infections and the development of secondary bacterial complications. Continue reading
It is well known that the nose performs respiratory, protective, resonant and olfactory functions. Free nasal breathing causes positive and negative pressure in the chest and abdominal cavities. When breathing through the mouth, the inspiration becomes less deep, this leads to a decrease in negative pressure in the chest and, as a result, a violation of the hemodynamics of the skull. With inflammation of the nasal mucosa, basic functions are violated and the quality of life is impaired.
Rhinitis (inflammation of the nasal mucosa) is a common pathology in children. According to various sources, in recent years, the frequency of diseases of the nose and paranasal sinuses in children has been 35–37%, of this number 50% of cases become chronic, each year the proportion of such patients increases by 1.5–2.0%. Continue reading
Treatment of infections of the upper respiratory tract, accompanied by the development of acute tonsillopharyngitis in children
Upper respiratory tract infections (UTI), or catarrhal diseases, are the most common diseases and are one of the main reasons children miss classes in kindergartens and schools. Most IVDPs are viral in nature, and more than 200 types of viruses can participate in the onset of the disease, in some cases other infectious agents, such as bacteria, become the cause. In children with an allergic and lymphatic-hypoplastic type of constitution, the course of IVPD is often complicated by acute inflammation of the lymphoid tissue of the pharyngeal ring. The cause of this lesion is often different viruses, but in some cases, bacteria such as group A streptococci, Streptococcus pneumoniae, Haemophilus influenzae and various types of Mycoplasma or Chlamydia, which are mainly transmitted by airborne droplets, can also participate in the pathological process. Continue reading
In order to focus attention on this problem of pediatricians, pediatric cardiologists and pulmonologists, we present an interesting clinical case of PAH on the background of a combination of BPD and congenital heart disease in a child with EBMT at birth.
A female child A., from the 1st pregnancy, which proceeded with the threat of termination in the first and second half, was born from 1 premature birth at the 26th week. gestation, by operation “cesarean section”, with a mass of 870 g and a length of 34 cm, with an Apgar score of 4/6 points.
From the first hours of her life, the girl had a serious condition with the manifestation of respiratory distress syndrome. Resuscitation measures were carried out using mechanical ventilation, oxygen therapy, surfactant replacement therapy, and a couvez regimen. On the 2nd day of life, a hemodynamically significant open ductus arteriosus (OAI) was detected, 3 doses of ibuprofen were used intravenously according to the usual scheme, without a positive effect. Continue reading
Pulmonary arterial hypertension (PAH) is a heterogeneous, often multifactorial condition that can be either an independent, isolated pathology, or a complication of a wide range of diseases, including congenital heart defects, bronchopulmonary dysplasia (BPD), bronchial asthma, genetic and chromosomal diseases, diseases connective tissue and other pathology. According to various estimates, the prevalence of PAH in childhood is rare, approximately 2–16 cases per 1 million children. However, in some risk groups, this pathology occurs many times more often [1, 2]. A significant part, more than 30% of cases, PAH is associated with pathology of the respiratory system, including BPD [3, 4]. Admittedly, the prevalence of pulmonary hypertension is often underestimated. Usually it is regarded as a long-term dynamic process that can occur only in the late stages of chronic bronchopulmonary disease. The initial stage of PAH occurs with a small, often intermittent increase in pressure in the pulmonary artery, which does not require a significant increase in the work of the right ventricle and, as a rule, does not have early clinical manifestations [5, 6]. Continue reading